Peptide synthesis refers to the procedure where amino acids are linked through peptide bonds to make short chains usually 30-50 amino acids in length. The method essentially involves one by one addition of amino acids which is an enzymatic action brought about by peptidyl transferase unit of the ribosome. Nature has provided numerous peptides for example insulin, oxytocin, glucagon, and glutathione which are very important in functions as cell growth, hormonal balancing, and collagen formation, thus making peptide synthesis an integral part of biochemistry, medical field, and cosmetic industry.
Key Growth Drivers and Opportunities
Rising Research & Development Activities: One of the reasons for market growth is the rise in research and development activities, which result in the production of advanced peptide synthesis methods that have higher yield, purity, and efficiency. The growth in R&D is also instrumental in the creation of new peptides to treat various diseases, creating a need for peptides in the pharmaceutical, biotechnological and cosmetic sectors.
Challenges
There are many issues that the peptide synthesis market has to deal with such as expensive production, complicated manufacturing processes and also the challenge to get long peptide sequences pure and stable. Besides the problems mentioned above, limited scalability and tough regulatory requirements can restrain the potential for going large scale in manufacturing and commercialization, thus causing the market’s growth to slow down.
Innovation and Expansion
A New Solid-Phase Peptide Synthesis Scale-Up Facility is Now Open
In January 2025, BioDuro, a leading Contract Research, Development, and Manufacturing Organization (CRDMO), announced the establishment of a fully automated solid-phase peptide synthesis scale-up laboratory on its Shanghai Zhangjiang High-tech Park location in China. This new facility expands the company’s peptide synthesis capabilities to fulfill the growing demand from global partners for efficient and scalable peptide manufacturing.
The cutting-edge kilogram-scale peptide laboratory is outfitted with automated solid-phase peptide synthesizers, cleavage systems, and freeze-drying equipment, allowing for peptide synthesis on a scale of up to 800 mmol. It is intended to generate a wide variety of peptide compounds, including as linear peptides, cyclic peptides, and different peptide drug conjugates.
Cambrex Introduces New Liquid-Phase Peptide Synthesis Manufacturing Technology
In September 2024, Cambrex, a leading global contract development and manufacturing organization (CDMO), announced that Snapdragon Chemistry, a Cambrex company, has successfully developed a new liquid-phase peptide synthesis (LPPS) technology that uses traditional active pharmaceutical ingredient (API) batch reactors and continuous flow, eliminating the need for specialized solid-phase reactors.
This innovative LPPS technique significantly minimizes solvent demand and the need for extra reagents when compared to traditional solid-state peptide synthesis processes. The LPPS method can handle peptides up to 12 residues long, and longer peptides are then formed in liquid phase utilizing a convergent fragment coupling approach. Cambrex’s LPPS technology enables processes to be scaled in the same way that traditional small molecules are.
Inventive Sparks, Expanding Markets
The key players operating the peptide synthesis market includes, Thermo Fisher Scientific, Kaneka Corporation, Merck KGaA, Bachem Holding AG, GenScript Biotech Corporation, Syngene, CEM Corporation, Lonza, Biotage AB, Novo Nordisk A/S, and others.
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