Liquid Kratom Extracts – Benefits and How It Works

Kratom liquid extract is an extract of the leaves of Mitragyna speciosa, a tree in the coffee family. Kratom has been used for centuries to relieve pain and improve mood. The extract can be prepared one of two ways: First, the leaves are crushed and boiled in water—the resulting mixture can either be ingested or dried into a powder that may be smoked or added to food. 

A second method involves boiling the leaves with vinegar, which forms alkaloids more soluble in water than those found in un-boiled kratom leaf extracts. Kratom liquid extract is most commonly sold in its raw form—mostly because it’s difficult to extract pure alkaloids from the leaves. However, it’s also available as a resin extract refined through additional filtration processes that produce a more concentrated product.

How does Kratom liquid extract work?

Kratom liquid extract works by activating certain opioid receptors in the brain, leading to pain relief, slowed breathing, and feelings of euphoria. 

These characteristics are similar to other opioids such as morphine or heroin, which is why kratom has been associated with some negative effects—most notably hallucinations, delusions, and psychosis. 

Although mitragynine may act on different pathways than classic opioids, its structure suggests binding to many of the same receptor sites. In addition, mitragynine appears to have more stimulant properties than classic opioid drugs.

Kratom liquid extract’s stimulant and sedative effects are dose-dependent: the more material you consume, the stronger its effects. This means that some users may not feel any major effects until they ingest several times their normal dosage of kratom liquid extract. However, this also means that it’s possible to overdose on mitragynine if too much is ingested at once or through repeated use.

Benefits of Kratom liquid extracts

Kratom liquid extract has many potential benefits. Much like other opioids, it’s thought to reduce pain by changing how your brain perceives it. Because kratom liquid extract activates certain opioid receptor sites in the brain, it can help people escape from the cycle of chronic pain associated with depression.

It also produces a mild sense of euphoria—a psychological reward that reinforces its use and allows users to circumvent their cravings for more traditional, harder drugs. Kratom liquid extracts are often compared to methadone in terms of effectiveness, but they don’t produce any serious side effects other than minor nausea, vomiting, or constipation.

And because kratom doesn’t have any major negative side effects when used correctly, some proponents sponsor kratom liquid extract as a safer alternative to other opioids. 

However, it’s not considered safe for use by people with pre-existing medical conditions such as substance abuse disorders, liver damage, asthma or respiratory problems, diabetes, depression, or any heart conditions because there’s no way to know if kratom liquid extract will interact negatively with your current medications or your current symptoms. 

Since the plant from which kratom comes is traditionally used in Asia, the Food and Drug Administration has also expressed concern about how little we still know about its potential health risks.

This lack of understanding combined with the risk for an overdose may have contributed to its illegal status in many states.

What are the side effects of Kratom liquid extract?

Kratom liquid extract has been associated with several potential side effects, depending on a person’s age, dose, and current medical conditions. For example, it can cause constipation or seizures when consumed in large doses by people who have existing liver problems. 

Because kratom itself is a stimulant, low doses also tend to lead to insomnia—which can be frustrating if you need to remain alert for an entire workday. When taken in high doses, kratom liquid extract may even act as a sedative an opioid (although this has yet to be proven).

The most common side effects are feelings of nausea, vomiting, or constipation. The exact cause is unclear, but it seems to stem from mitragynine stimulating the muscles in the stomach and intestines. 

Higher doses have also been associated with symptoms such as dry mouth, loss of appetite, fatigue, bloodshot eyes, skin discoloration, blurred vision, and hot flashes.

What are the health effects of Kratom liquid extract?

Kratom has been prized for thousands of years as a natural remedy for pain, fatigue, and depression. In small doses, kratom can feel stimulating, while larger doses have a calming effect. 

Although stimulant effects were once thought to be due to adrenaline production, scientists now believe those effects may be attributable to one or more of its active ingredients: mitragynine, 7-hydroxy mitragynine, paynanthine, speciogynine, and speciofoline. 

Kratom liquid extract has been used successfully to manage the withdrawal symptoms of opium addiction, but it should not be considered a replacement for professional medical detox.


Kratom liquid extract is not currently recognized as an effective treatment for medical conditions. Its properties are virtually identical to traditional, harder opioids like heroin or oxycodone; however, its standardized concentration means that it’s much easier to overdose on because you don’t need very much at once. The cost-effectiveness of kratom liquid extracts (compared with the price of other opiates) may be part of why they’re becoming popular. But, like all drugs, people should use them under their doctor’s supervision to minimize risks and maximize potential benefits.


Nishi Singh is a professional journalist and editor in New Delhi. She has studied Mass Communication from National Institute of Mass Communication.