Oligonucleotides are short chemically produced fragments of nucleic acids and are the most widely used molecules in research, diagnostics, education, industry, and medicine. They can be synthesized either professionally for large-scale usage or self-initiated using DNA synthesizers. The development in the synthesis, amplification, and automation has changed the landscape of biological research a lot. Now, researchers can customize quickly and still get an online access. The total cost of a synthesis depends on several factors including error rates, cycle times, throughput, and price per base pair.
Key Growth Drivers and Opportunities
Decrease in Cost of DNA Sequencing: The cost of genome sequencing has been reduced significantly thanks to genomics and NGS technology. The price was USD 5 million in 2008 and it went down to about USD 1,000 in 2017. Besides cost, the speed has been increased as well. Nowadays, sequencing finds application in reproductive medicine, cancer, diseases caused by infection, and deciphering the genetic basis of human disorders.
Challenges
The oligonucleotide synthesis market has several challenges namely high production costs, the occurrence of errors in the process of synthesis, the inability to increase the length of the sequences in a scalable manner, a dependence on special equipment, and some regulatory issues that result in a partial adoption of this market and also have an impact on the effectiveness of research and drug applications.
Innovation and Expansion
Synoligo Biotechnologies Introduces a Cutting-Edge E-Commerce Platform for Oligonucleotide Synthesis, Providing Researchers with Streamlined Access
In July 2025, Synoligo Biotechnologies Inc., a custom oligonucleotide synthesis leader, has announced the introduction of a new e-commerce website that will revolutionize academics’ access to high-quality oligonucleotides. The platform meets essential demands in the scientific community by providing unprecedented convenience, speed, and customization for oligonucleotide synthesis orders.
The global market for oligonucleotide synthesis is increasing fast, driven by new applications in diagnostics, pharmaceuticals, and basic research. Synoligo’s new digital solution seeks to streamline the ordering procedure and improve the overall experience for scientists globally.
Oligo Factory Introduces Low-Scale Oligo Synthesis Capability to Expand Support for Therapeutic and Diagnostic Researchers and Developers
In May 2025, Oligo Factory, a leading science-driven manufacturer of high-quality bespoke DNA and RNA oligonucleotides for medicinal, diagnostic, and life science applications, has announced the availability of its new low-scale oligo synthesis capabilities. This expansion strengthens the company’s ability to provide support for the whole development lifecycle of oligo-based therapies, including discovery, preclinical and toxicity research, and molecular diagnostic applications.
Oligo Factory will demonstrate its new and comprehensive FactorTx for Therapeutics product line, which comprises low- and mid-scale oligo synthesis stages, at TIDES USA, which takes place in San Diego from May 19 to 22.
Inventive Sparks, Expanding Markets
The key players operating in the oligonucleotide synthesis market includes Integrated DNA Technologies, Inc. (Part of Danaher Corporation), Merck KGaA, Eurofins Scientific SE), Thermo Fisher Scientific Inc., Agilent Technologies, Inc., GE Healthcare, GeneDesign, Inc., (Part of Ajinomoto Co.,Inc.), Kaneka Eurogentec (Belgium) (Part of Kaneka Corporation), LGC Biosearch Technologies, Bio-synthesis Inc., TriLink BioTechnologies, LLC (Part of Maravai LifeSciences), and ATDBio Ltd., and among others.
About Author:
Prophecy is a specialized market research, analytics, marketing and business strategy, and solutions company that offer strategic and tactical support to clients for making well-informed business decisions and to identify and achieve high value opportunities in the target business area. Also, we help our client to address business challenges and provide best possible solutions to overcome them and transform their business.
