HEALTH

Folic Acid and Folate

Folate, or Vit B-9, is a water-soluble, important nutrient found in nature. It also creates folic acid, a nutrient that is commonly added to foods and supplements. A deficiency of folate is one of the most common nutritional deficiencies. Vit B-9, on the other hand, is essential for a variety of body functions. The major source of this deficiency is a diet lacking in folate-rich meals. However, many people have health problems that make it difficult to absorb natural folate.

What factors have an impact on my folate levels?

Furthermore, 50% of the world’s population believes they have an MTHFR gene mutation that they received from their parents. The MTHFR gene produces the methylenetetrahydrofolate reductase enzyme. It is necessary for the conversion of folate to the active form L-methyl folate in the chemical process (5-MTHF). The conversion of homocysteine to methionine, an amino acid, is required for this activity. Methionine is required for the production of proteins such as dopamine, serotonin, melatonin, and epinephrine, which are neurotransmitters. Neurotransmitter deficits are frequently linked to severe sorrow and other mental disorders.

What does it mean to eat a “fortified” diet, exactly?

A number of foods have been “fortified” with artificial folic acid. However, quite so much folic acid in the body can cause problems, particularly in the elderly. Folic acid takes far longer to break down than natural folate, even with optimum folate metabolism. It must be activated with the help of the liver and other tissues. It works in a somewhat different way than folate, which is generally immediately biotransformed following intestinal absorption. L-methylfolate, but at the other hand, bypasses the folic acid metabolism cycle entirely and is more effective than folic acid for increasing circulation active folate.

What Are the Benefits of L-Methylfolate?

L-methylfolate is a nutritional supplement that can help you acquire more active folate in your bloodstream, which can help you get rid of homocysteine. L-methylfolate does not propose therapy since nutritional supplements cannot guarantee that they will be utilised to cure diseases or conditions. This active component is the only one in Deplin®, a medical food with a nutritious composition. It’s made specifically for depressed folks. Of course, before making any changes to your health regimen, you should always see your doctor. L-methylfolate, on the other hand, permits your body to bypass the folic acid cycle while still obtaining all of the vitamin B-9 advantages. L-methylfolate may be precisely what your body needs to boost your mood if you have an MTHFR mutation.

References:

DEPLIN Website. Covington, LA: Alfasigma USA, Inc.; 2017. www.deplin.com

Lamers, Yvonne, et al. “Supplementation with [6 S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women.” The American journal of clinical nutrition 79.3 (2004): 473-478.

LeBano, Lauren. “L-Methylfolate: A Promising Therapy for Treatment-Resistant Depression?” Psyche Congress Network. May 8, 2013. www.psychcongress.com/article/l-methylfolate-promising-therapy-treatment-resistant-depression

Leech, Joe. “L-Methylfolate (5-MTHF): Your Must-Read Beginner’s Guide.” Diet vs. Disease. May 13, 2018. https://www.dietvsdisease.org/l-methylfolate-5-mthf/

Miraglia, Niccolo, et al. “Enhanced oral bioavailability of a novel folate salt: comparison with folic acid and a calcium folate salt in a pharmacokinetic study in rats.” Minerva ginecologica 68.2 (2016): 99-105.

Papakostas, George I., et al. “L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials.” American Journal of Psychiatry 169.12 (2012): 1267-1274.

Patanwala, Imran, et al. “Folic acid handling by the human gut: implications for food fortification and supplementation–.” The American journal of clinical nutrition 100.2 (2014): 593-599.

Scaglione, Francesco, and Giscardo Panzavolta. “Folate, folic acid and 5-methyltetrahydrofolate are not the same thing.” Xenobiotica 44.5 (2014): 480-488.

Stahl, Stephen M. “Brainstorms: L-Methylfolate: A Vitamin for Your Monoamines.” The Journal of clinical psychiatry 69.9 (2008): 1352-1353.

Venn, Bernard J., et al. “Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study.” The American journal of clinical nutrition 77.3 (2003): 658-662.


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