Cannabigerol: Understanding the Role of CBG in Cannabis

March 12, 2021June 17, 2021 markcortes Cannabigerol

Cannabigerol is one of the many compounds found in cannabis plants. CBG can be synthesized from cannabigerolic acid, which is a parent molecule from which other Cannabinoids are produced. CBG is naturally occurring and most of it gets converted into THC or CBD during plant growth. It’s rare to find high levels of CBG in the plant, but there are products available that contain this Cannabinoid compound at a higher concentration than normal. CBG is not psychoactive, meaning it doesn’t have any mind-altering properties.

The human body has CB receptors located in the brain and other parts of the immune system. The CB receptor gene can be found on chromosome 13q14 region for males and 16p13 region for females. Isolated CBG acts as a negative allosteric modulator of PPARs which are powerful regulators of genes involved in chronic inflammatory diseases such as Crohn’s disease, ulcerative colitis, renal failure, or stomach ulcers caused by Helicobacter pylori bacteria. Cannabigerol appears to affect these conditions through its ability to reduce inflammation while sufficiently maintaining bone strength due to its anti-proliferative and anti-inflammatory properties.

Liferesearchco CBG can promote apoptosis in some types of cancer, such as pancreatic and breast cancers. CBG also inhibits tumor growth, induces cell cycle arrest, and exerts a regulatory effect on angiogenesis (blood supply to the tumors)

The benefits of CBD are well established, but there is still not enough research done with CBGs effects on humans or animals so it’s difficult to draw conclusions about what its potential use may be for health problems. Further studies need to be conducted before any claims can be made either way. We do know that CBGs have shown less side effects than hemp derived CBD because they’re significantly lower in THC, which means you won’t get high from them like you would from CBD.

Cannabigerol – CBG Products:

Cannabigerol (CBG) is one of more than 120 identified Cannabinoid compounds found in the plant genus Cannabis. Cannabigerol is the decarboxylated form of Cannabigerolic acid, the parent molecule from which other Cannabinoids are synthesized and it’s a minor constituent of cannabis plants during growth with most converted to THC or CBD leaving about 0.06% CBG on average after production for use as an extract product.

CBD is currently being researched as an alternative to current treatments of epilepsy, psychosis, and chronic pain. CBG has not been given the same level of research attention, but it’s possible that CBD could have a synergy with CBGs effects on brain function or immune system functioning so more studies need to be conducted before this will become apparent.

CBG Products may also help in combating Alzheimer’s disease and cancer cell growth by activating cannabinoid receptors, which are found throughout our bodies, including within the central nervous system, immune cells, endocrine glands, skin tissue, and reproductive organs. As there is still little known about its role in humans, though further research needs to be done for clinical purposes, both animal models and human studies are currently underway to explore CBG’s effects.

CBG is a lesser known Cannabinoid found in cannabis, but it could have some important uses when used as an extract or purified form of the molecule, particularly for mitigating chronic pain and neurological disorders like epilepsy and schizophrenia. It has also been shown that CBD can help with symptoms associated with Alzheimer’s disease such as neuroinflammation which would support its use alongside CBGs anti-inflammatory properties. Cannabis oil, containing both THC and CBD together may also be able to combat cancer cell growth by activating cannabinoid receptors throughout the body, including within the central nervous system, immune cells, endocrine glands, skin tissue and reproductive organs – this synergistic effect needs more research before we know whether there will be any promising outcomes.

CBG is also a precursor to THC and CBD, meaning that it’s the key molecule in the cannabis plant responsible for producing these other primary Cannabinoids. Unlike its Cannabinoid cousins, CBG does not produce psychoactive effects as it has a low affinity CB receptors, which are typically involved in creating such reactions when activated by compounds like THC or CBD.

It appears that some strains of Cannabis have been bred over time to heighten their levels of certain components including Cannabigerol (CBGs). However, there is very little research on this compound so we don’t know if those elevated concentrations will be found across all Cannabis plants grown from seeds created from high-CBD genetic. Previous research has indicated that CBG may offer therapeutic effects for those with chronic pain.

Pharmacological studies have found CBG to be a strong inhibitor of cellular respiration and act as an antimicrobial agent, making it promising in the treatment of fungal infections like Candida. CBG’s ability to inhibit certain enzyme activity is also being researched, but additional research on this topic will enable us to know more about its potential pharmaceutical uses.”

There is very little research on this compound so we don’t know if those elevated concentrations will be found across all Cannabis plants grown from high CBD genetic. Previous research has indicated that CBGs may offer therapeutic effects for those with chronic pain, and pharmacological studies have found CBG to be a strong inhibitor of cellular respiration as well as act as an antimicrobial agent making it promising in the treatment of Candida fungal infections. Its ability to inhibit certain enzyme activity is also being researched, but additional research will enable us to know more about its potential pharmaceutical uses.