During his tenure at Mayo Clinic, Jan Van Deursen developed a reputation for being difficult and demanding. He would work seven days a week, almost without a day off. Yet, his research was highly successful, and he was a well-respected scientist who won numerous awards. But the pressure cooker scientist also caused him to become an enigma, with little time to himself or to have a family.
After earning his Ph.D. from the University of Nijmegen, Jan Van Deursen joined the St. Jude Children’s Research Hospital in Memphis, Tennessee. In 1999, he established a curiosity-driven research program at Mayo Clinic. From 1999 to 2020, he was the head of the transgenic and gene knockout core facility at the Mayo Clinic. He later became the chair of the Biochemistry and Molecular Biology department at the Mayo Clinic.
After joining the Mayo Clinic in 1999, Jan Van Deursen created a mouse gene knockout core facility to advance his research program. He also developed a genetic knockout core facility at Mayo Clinic and has published his research findings in prestigious journals. In addition to his own research, Jan Van Deursen is passionate about translating his discoveries into medicine for unmet needs. If you want to know more about his work, take a look at some of his publications:
His discoveries on senescent cells are groundbreaking. They link aging to the accumulation of senescent cells in the body. As a result, he is co-founder of Unity Biotechnology, a publicly traded biopharmaceutical company focused on finding ways to remove these cells. The company is now gearing up for clinical trials on osteoarthritis and glaucoma. Currently, Dr. van Deursen is a part-time researcher at Unity Biotechnology.
As a Mayo Clinic chair, Jan Van Deursen championed diversity among the faculty. The biochemistry department filled 5 of six tenure-track positions with diverse candidates. Dr. Van Deursen worked with Mayo Clinic leadership to improve mentoring programs and institutional support for non-tenure-track faculty. During his tenure, Dr. Van Deursen’s research lab remained diverse, despite his high-profile position.
Millions of dollars currently support the van Deursen lab in grants from the National Institutes of Health. Van Deursen’s lab focuses on aging and senescent cells. By understanding these processes, doctors may find ways to cure cancer or extend life. The research of Jan Van Deursen has already spawned a spin-off company, Unity Biotechnology, which is now a major success. It has attracted big investors, including the world’s richest man Jeff Bezos.
As a cell biologist at Mayo Clinic, Jan Van Deursen has been an innovator in tackling the problem of aging and senescent cells. His research has centered on these cells, which accumulate in our bodies and may contribute to physical decline as we age. His research at the Mayo Clinic is a perfect match for Mayo Clinic’s student-centered graduate program. It has even led to the development of new treatments for aging.
In addition to his work as a biochemist, Jan Van Deursen has mentored dozens of young scientists and aspires to become a principal investigator. This path to independence begins with funding. His research has also helped Dr. Childs become a successful physician-scientist. His mentor, Jan Van Deursen, Ph.D., is a mentor who helps young scientists get the initial boost they need to make progress.
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